Sheela Abraham

Sheela Abraham, Ph.D

Assistant Professor, Queen's University, Kingston

Biography

Our research involves interrogating signalling events critical to the development and maintenance of both normal haematopoietic and cancer stem cells. To accomplish this, our research integrates biochemical and molecular biological techniques, primary human tissue culturing techniques, nanoparticle characterization and sizing, chromatography, mass spectrometry (MS), RNA sequencing (RNAseq) microscopy, flow cytometry, bioinformatics and network analyses. Haematopoietic stem cells are critical in the replenishment and health of blood thus faults in the maintenance of these cells form the basis of haematopoietic malignancies. Haematopoietic stem cells depend on both intra and extracellular signalling events that take place within the bone marrow microenvironment. Evidence indicates that extracellular vesicles (EVs) provide a key role in cell-to-cell communication. Cells produce EVs (or nanoparticles) that can be either endosomally derived vesicles (30-120 nm) or directly formed from the plasma membrane (100 nm-1 µm), and can contain nucleic acids and proteins. The biogenesis of EVs has been observed in unicellular organisms to mammals, thus suggesting an evolutionarily conserved mechanism of cellular communication.

Funded Projects

Extracellular vesicles in aging and clonal hematopoiesis »



Research Specialties

Research Interests

  • Hematological
  • Molecular Pathology

Contact for Collaboration

Queen's University
99 University Avenue
Kingston, ON, K7L 3N6
Pathologists and Researchers who are interested in being part of the OMPRN: