Phedias Diamandis

Dr. Phedias Diamandis

Principal Investigator , University Health Network, Toronto


I completed my Doctoral, Medical and Residency training in Neuropathology here at the University of Toronto. I carried out my PhD work under the mentorship of Professors Peter Dirks and Mike Tyers in neural stem cell and cancer stem cell biology. By harnessing the chemical diversity housed within small molecule libraries, we were able to uncover novel regulators of neural and cancer stem cell function. Outside of work, I enjoy spending time with family and playing sports including tennis and running.

Our current research program focuses on strategic application of contemporary and comprehensive molecular tools to improve our understanding of neurobiology, neuroanatomy and microscopic characterization of disease. Our most recent large scale efforts have focused on mass spectrometry based proteomic methods to profile human neural tissue and expand our understanding of cancer and neurodevelopment. We use the generated datasets as a springboard for more focused mechanistic studies and novel biomarker discovery of neuropathological diseases.

Funded Projects

Development of deep learning tools for deciphering intra-tumoral heterogeneity and predicting drug response in High Grade Serous Ovarian Cancer »

Brain Tumour Assembloids as Personalized Avatars for Glioblastoma Drug Discovery »

Proteomic biomarker discovery in clinically malignant meningiomas »

Research Specialties

Research Interests

  • Molecular Pathology
  • Neuropathological

Contact for Collaboration

University Health Network
Pathologists and Researchers who are interested in being part of the OMPRN: